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目的本研究旨在探讨血清细胞因子IL-13、TNF-a在支气管哮喘、慢性阻塞性肺疾病(COPD)患者中的浓度变化,探讨IL-13、TNF-a与哮喘、慢性阻塞性肺疾病(COPD)的发病机理以及诊疗中意义。方法40例支气管哮喘C Asthma),40例慢性阻塞性肺疾病(COPD)患者及20例健康对照者,入院时进行肺功能检杳,同时抽取静脉血,用酶联免疫吸附试验(ELISA)测定血清中的细胞因子IL-13(白细胞介素13),TNF-a(肿瘤坏死因子)的浓度。结论支气管哮喘及COPD急性发作期患者的血清IL-13、TNF-α的浓度明显高于健康对照组(P<0.01)。提示IL-13、TNF-α细胞因子参与支气管哮喘及COPD发病的机制。
Objective To investigate the changes of serum cytokines IL-13 and TNF-α in patients with bronchial asthma and chronic obstructive pulmonary disease (COPD), and to explore the relationship between IL-13, TNF-a and asthma, chronic obstructive pulmonary disease (COPD) pathogenesis and diagnosis and treatment of significance. Methods Forty asthmatic patients with asthma (C Asthma), 40 patients with chronic obstructive pulmonary disease (COPD) and 20 healthy controls were enrolled. Pulmonary function tests were performed at the time of admission. Venous blood was drawn at the same time and was measured by enzyme - linked immunosorbent assay (ELISA) Serum levels of cytokines IL-13 (Interleukin 13), TNF-a (tumor necrosis factor). Conclusions Serum levels of IL-13 and TNF-α in patients with bronchial asthma and acute exacerbation of COPD are significantly higher than those in healthy controls (P <0.01). Prompt IL-13, TNF-α cytokines involved in the pathogenesis of bronchial asthma and COPD.