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目的:比较爱莎吸乐与喘乐宁气雾剂治疗儿童哮喘急性发作的疗效。方法:采用多中心、随机、开放力法研究140例(随机分成两组)4～11岁患儿单次吸入爱莎吸乐或喘乐宁气雾剂(含沙丁胺醇200μg)后的疗效,测定吸药前及吸药后5、15、30、120min的心率、呼吸、哮鸣音评分、最大呼气流量(PEF)指标。结果:两组年龄、性别、心率、呼吸、PEF等一般指标具可比性,两组吸药前后比较心率、呼吸频率下降,哮鸣音明显减少,PEF明显改善,有显著性差异。爱莎吸乐组各时间点心率下降较喘乐宁组更明显,120min时平均PFF改善值高于喘乐宁组(P<0.05)。结论:哮喘患儿用两种不同压力定量气雾剂吸入沙丁胺醇后,爱莎吸乐组临床指标和PEF改变更优于喘乐宁组。
OBJECTIVE: To compare the efficacy of Aesar and Lelemine aerosol in the treatment of acute asthma attacks in children. Methods: A multicenter, randomized and open-ended study was conducted to investigate the efficacy of a single inhalation of Aesar Fuller or Salbutamol Aerosol (containing salbutamol 200μg) in children aged 4 to 11 years (randomly divided into two groups) Heart rate, respiration, wheeze score and maximum expiratory flow (PEF) at 5, 15, 30, 120 min before and after inhalation. Results: The two groups were comparable in age, gender, heart rate, respiration, PEF and other general indicators. The heart rate and respiratory rate of the two groups were decreased before and after inhalation. The wheeze was significantly reduced and the PEF was significantly improved with significant difference. Heart rate of Asha inhaling group decreased more significantly than that of salbutamol at each time point. The improvement of average PFF at 120min was higher than that of salbutamol (P <0.05). Conclusion: After inhaling albuterol with two different doses of aerosol in children with asthma, the changes of clinical indexes and PEF in Aesar pleural group were better than those in asthmane group.