疾病状态的药物干预是内科治疗的重要方法之一,药物疗效和安全性在疾病治疗中具有同等重要的作用。对于癫痫这一慢性脑疾病而言,由于患者需要接受长期的药物治疗,故其安全性显得尤为重要。自Isoj(a|¨)rvi报告丙戊酸(VPA)可引起女性癫痫患者生殖内分泌系统功能失调后,有关抗癫痫药物(AEDs)对内分泌系统的影响即成为癫痫药物治疗研究的焦点。 Drug interventions for disease states are one of the most important medical treatments, and their efficacy and safety are equally important in the treatment of diseases. For epilepsy, a chronic brain disease, its safety is of particular importance because it requires long-term medication. Since Isoj (a |) rvi reports that valproic acid (VPA) can cause reproductive and endocrine disorders in women with epilepsy, the impact of antiepileptic drugs (AEDs) on the endocrine system has become the focus of epilepsy drug therapy research.