红霉素经近40年的临床应用,其不良反应也日渐增多,有些反应相当严重,甚至可导致死亡,为充分认识红霉素的严重不良反应,现将近几年来报道的不良反应综述如下:一、消化系统的不良反应1.胃肠道反应文献报道红霉素服后出现恶心、呕吐、腹痛、腹泻等约2%,反应与剂量有关,如成人6小时超过0.5g 易出现。有报告12例患者,男性8例,女性4例,年龄40～52岁,口服红霉素后 After nearly 40 years of clinical application of erythromycin, its adverse reactions are also increasing, and some reactions are quite serious, and even lead to death. In order to fully understand the serious adverse reactions of erythromycin, the adverse reactions reported in recent years are summarized as follows: First, the adverse reactions of the digestive system 1. Gastrointestinal reactions reported in the literature after erythromycin serving nausea, vomiting, abdominal pain, diarrhea, about 2%, the reaction dose-related, such as adults more than 0.5g 6 hours prone to appear. There are reports of 12 patients, 8 males and 4 females, aged 40 to 52 years, after oral administration of erythromycin