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1973年,Holman报道在冠状动脉闭塞后24小时,可用静脉注射~(99m)锝—四环素观察闭胸狗的心肌梗塞部位。不久,Bonte报道用~(99m)锝—焦磷酸盐(~(99m)Tc—PYP)取得了类似的结果。此后,Holman和Willerson又分别报道了两组梗塞闪烁图病例,从而引起了对这一重要诊断方法的兴趣。虽然梗塞显影剂在损伤心肌内积聚的机理尚不明,显然,它们能选择性地在急性坏死的心肌内浓集,不论心肌坏死的原因孰何,因此,梗塞闪烁图阳性系直接检出心肌的急性损伤。这与铊—201灌注闪烁图或同位素心室图等心肌显影技术有所不同,后者仅是在某些临床情况下,通过显示局限性的灌注缺损或节段性心室功能不良而间接地作出急性梗塞的诊断。
In 1973, Holman reported that at 24 hours after the occlusion of the coronary artery, the ~ (99m) technetium-tetracycline can be administered intravenously to observe the infarction of the thoracodorsal dog. Soon, Bonte reported similar results with ~ (99m) technetium-pyrophosphate (~ (99m) Tc-PYP). Since then, Holman and Willerson have separately reported two cases of infarction scintigraphy, which led to interest in this important diagnostic method. Although the mechanism by which infarct developers accumulate in the injured myocardium is not known, it is clear that they selectively concentrate in acutely necrotic myocardium irrespective of the cause of myocardial necrosis. Therefore, an infarct scintigraphy positive is directly detected in the myocardium Acute injury. This is in contrast to myocardial imaging techniques such as thallium-201 perfusion scintigraphy or isotope ventricular mapping, which is only indirectly in some cases clinically acute by displaying localized perfusion defects or segmental ventricular dysfunction Diagnosis of infarction.