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已有文献报道,饲喂含0.05～0.5%BHT(2,6—二叔丁基对甲酚)的饲料可以促进化学物诱发的A/J种系小鼠肺癌的发生。研究表明只有对已接触致癌剂的动物,BHT才能显示促癌作用。然而,仅有A/J小鼠的资料还很难确定作为持续应用的食品添加剂BHT是否会引起人类某些肿瘤发病率上升。本实验的目的是研究BHT对其它种系小鼠和肺以外器官肿瘤
It has been reported in the literature that feeding of feed containing 0.05-0.5% BHT (2,6-di-tert-butyl-p-cresol) can promote the carcinogenesis of lung cancer in chemical-induced A / J mice. Studies have shown that BHT can show cancer-promoting effects only in animals that have been exposed to carcinogens. However, it is difficult to determine whether the continuous use of BHT as a food additive causes an increase in the incidence of certain cancers in humans, but only in A / J mice. The purpose of this experiment was to investigate the effects of BHT on other germline mice and organ tumors outside the lung