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为探讨慢性炎症、良性肿瘤和癌症患者１级亲属外周血细胞的细胞生物学特性，采用流式细胞术单参数ＤＮＡ检测法，研究受检者外周血单个核细胞的Ｓ期细胞比率（Ｓｐｈａｓｅｆｒａｃｔｉｏｎ，ＳＰＦ）、增殖指数（ｐｒｏｌｉｆｅｒａｔｉｏｎｉｎｄｅｘ，ＰＩ）和细胞凋亡（ａｐｏｐｔｏｓｉｓ，Ａｐｏ）的变化规律。结果显示，慢性炎症、良性肿瘤和癌症患者１级亲属的外周血单个核细胞ＳＰＦ、ＰＩ和Ａｐｏ均显著高于健康对照者（Ｐ值分别＜０．０１、＜０．０５和＜０．０１）。该结果提示，慢性炎症、良性肿瘤和癌症患者１级亲属的外周血单个核细胞的生物学特性确实发生了一些变化，而这些变化与癌症患者血细胞变化规律十分相似。
To investigate the cytobiological characteristics of peripheral blood cells in chronic inflammation, benign tumors, and cancer patients’ first degree relatives, single-parameter DNA detection using flow cytometry was used to study the S-phase fraction of peripheral blood mononuclear cells in the subjects. , SPF), proliferation index (PI) and apoptosis (apoptosis, Apo) changes. The results showed that SPF, PI, and Apo in peripheral blood mononuclear cells from patients with chronic inflammation, benign tumors, and cancer relatives were significantly higher than those from healthy controls (P <0.01, <0.05, and <0.01, respectively). ). This result suggests that the biological characteristics of peripheral blood mononuclear cells in chronic inflammation, benign tumors, and cancer patients’ first-degree relatives do have some changes, and these changes are very similar to those of cancer patients.