内科应用抗菌药物预防在下列情况下最可能获得成功:(1)药物用以预防单一菌种的感染;(2)这种微生物对所用药物完全敏感,且能继续保持敏感性;(3)所用药物的副作用少。风湿热的预防风湿热仅伴随化脓性链球菌感染之后发作,最初使用磺胺预防风湿热时,并不令人满意;在美国武装部队中,大规模应用磺胺嘧啶导致耐磺胺链球菌的出现和蔓 Medical applications Antibacterial prophylaxis is most likely to be successful in the following situations: (1) the drug is used to prevent infection with a single strain; (2) the microorganism is completely sensitive to the drug used and can remain sensitive; (3) Less side effects of drugs. Prevention of Rheumatic Fever Rheumatic fever is associated only with septicemia after S. pyogenes infection and was initially unsatisfactory with sulfa for the prevention of rheumatic fever; in the U.S. Armed Forces, large-scale use of sulfadiazine led to the emergence of S. & lt; RTI ID = 0.0 & gt;