论文部分内容阅读
目的探讨低剂量米非司酮治疗子宫内膜异位症的疗效。方法 2 2例子宫内膜异位症患者口服米非司酮 12 .5 mg,1次 /d,连续3～ 6个月。比较治疗前后症状、体征及血激素水平。结果在治疗期间所有患者均闭经 ,与治疗前比较 ,总主观症状评分于治疗 3个月后下降了 82 .6% ,6个月后下降了 93 .5 % (P<0 .0 1) ;内膜异位症病灶于 3个月后缩小了 3 2 .8% ,6个月后缩小了 5 8.2 % (P<0 .0 1)。用药 3个月血孕激素水平比用药前显著降低 ,雌激素水平降至卵泡中期水平 ,黄体生成素、促卵泡激素水平均无变化。停止治疗后于2 4～ 40天恢复月经。不良反应为潮热、恶心及乏力。结论低剂量米非司酮治疗子宫内膜异位症效果良好 ,副作用小 ,是治疗子宫内膜异位症的又一种保守治疗方法
Objective To investigate the efficacy of low-dose mifepristone in the treatment of endometriosis. Methods Twenty-two patients with endometriosis received oral mifepristone 12.5 mg once daily for 3-6 months. Before and after treatment of symptoms and signs and signs of blood hormone levels. Results All patients underwent amenorrhoea during the treatment. Compared with those before treatment, the total subjective symptom score decreased by 82.6% after 3 months of treatment and 93.5% (P <0.01) after 6 months. Endometriosis lesions decreased by 32.8% at 3 months and by 5 8.2% at 6 months (P <0.01). Blood progesterone levels in 3 months after treatment were significantly lower than those before treatment, estrogen levels were reduced to mid-follicle levels, and there was no change in luteinizing hormone and follicle-stimulating hormone levels. Menstruation was resumed after 24 to 40 days after stopping treatment. Adverse reactions to hot flashes, nausea and fatigue. Conclusion Low dose of mifepristone treatment of endometriosis with good results, side effects, is a conservative treatment of endometriosis