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目的:研究木棉花总黄酮对高脂血症大鼠血脂的影响。方法:雄性SD大鼠随机分为空白组、模型组、阳性对照阿托伐他汀钙片组(5 mg/kg)、木棉花总黄酮组(100 mg/kg,200 mg/kg,400 mg/kg)。除空白组外,其余组每天灌胃给予10 ml/kg高脂乳剂,一周后,在每天灌胃高脂乳剂的基础上,每日灌胃给药1次,连续给药30 d,空白组与模型组每天灌服等体积的生理盐水。测定大鼠血清中总甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)的水平和大鼠血清载脂蛋白AⅠ(apoAⅠ)和载脂蛋白B100(apoB100)的含量,并检测大鼠全血黏度、血浆黏度、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血活酶时间(TT)和纤维蛋白原含量(FIB)。结果:与模型组比较,木棉花总黄酮(100,200,400 mg/kg)能降低高脂血症大鼠血清中TG、TC、LDL-C和apoB100的含量,升高HDL-C和apoAⅠ的含量,降低全血黏度和血浆黏度,同时能显著性延长PT、APTT和TT及降低FIB。结论:木棉花总黄酮具有显著降血脂作用,其机制可能与调节载脂蛋白和改善血液流变学有关。
Objective: To study the effect of kaki cotton total flavonoids on blood lipids in hyperlipidemic rats. Methods: Male SD rats were randomly divided into blank group, model group, positive control atorvastatin calcium group (5 mg / kg), kaki cotton total flavonoids (100 mg / kg, 200 mg / kg, 400 mg / kg). In addition to the blank group, the remaining groups were given intragastric administration of 10 ml / kg of high-fat emulsion, one week later, on the basis of daily high-fat emulsion gavage, once daily intragastric administration, continuous administration of 30 d, blank group The rats in model group were fed with equal volume of normal saline daily. The levels of total triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and serum apolipoprotein A (apoAⅠ) and apolipoprotein B100 (apoB100) in rats were determined. The whole blood viscosity, plasma viscosity, prothrombin time (PT), activated partial thromboplastin time (APTT) and thromboplastin time (TT) And fibrinogen content (FIB). Results: Compared with the model group, the total flavonoids of kaki cotton (100, 200 and 400 mg / kg) decreased the content of TG, TC, LDL-C and apoB100 in the serum of the hyperlipidemic rats and increased the levels of HDL-C and apoAⅠ Whole blood viscosity and plasma viscosity, while significantly prolonging PT, APTT and TT and reducing FIB. Conclusion: The total flavonoids of kaki cotton have significant hypolipidemic effect, and its mechanism may be related to the regulation of apolipoprotein and improvement of hemorheology.