目的 :评价术中放疗联合区域动脉灌注治疗局部晚期胰腺癌的效果。方法 :17例局部晚期胰腺癌减黄手术时行术中放疗(IORT) ,胃网膜右动脉插管行 5 -氟尿嘧啶( 5 FU ) +表阿霉素 (EPI) +丝裂霉素(MMC)方案的区域灌注化疗 ,其中 6例术后行外照射放疗。结果 :疼痛缓解率70 5 9% ( 12 / 17) ,临床受益指数 3 5 2 9%( 6/ 17) ,局部病灶部分缓解 2 3 5 3 % ( 4 / 17)。中位生存 11个月 ,1年生存率 3 5 2 9%( 6/ 17)。结论 :IORT结合区域动脉灌注化疗毒副作用轻微 ,可明显提高临床受益率 ,延长生存期 Objective: To evaluate the effect of intraoperative radiotherapy combined with regional arterial infusion in the treatment of locally advanced pancreatic cancer. Methods: Seventeen patients with locally advanced pancreatic cancer undergoing yellowing surgery underwent intraoperative radiotherapy (IORT), 5FU + epirubicin (EPI) + mitomycin C (MMC) ) Regimen regional perfusion chemotherapy, 6 cases were treated with external beam radiotherapy. Results: The pain relief rate was 70 59% (12/17), the clinical benefit index was 3529% (6/17), and the local lesion was partially relieved (23/31). The median survival was 11 months, and the 1-year survival rate was 3 5 2 9% (6/17). Conclusion: IORT combined with regional arterial infusion of chemotherapy has mild side effects, can significantly improve the clinical benefit rate and prolong survival