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E1040是一种新型注射用头孢菌素,其化学结构如下: 本品对非葡萄糖发酵的绿脓杆菌和乙酸钙不动杆菌以及对第三代头孢菌素高度耐药的肠杆菌属和柠檬酸细菌属等革蓝氏阳性和阴性菌有广泛的抗菌活性。毒物学研究表明本品与目前使用的其它头孢菌素一样安全。考虑本品的安全性及其在临床上的作用,作者决定对其进行1期临床研究以测定本品对健康男性成人的耐受性和药代动力学。 48名健康男性志愿者,年龄23～47岁,体重53～79kg,身高为162～185cm。首先,
E1040 is a new cephalosporin for injection, its chemical structure is as follows: This product is non-glucose fermentation of Pseudomonas aeruginosa and Acinetobacter calcoaceticus and third generation cephalosporins highly resistant Enterobacter and citric acid Bacteria and other leather blue positive and negative bacteria have a wide range of antibacterial activity. Toxicology studies have shown that this product is as safe as other cephalosporins currently used. Considering the safety of this product and its clinical role, the authors decided to conduct a phase 1 clinical study to determine the product’s tolerance and pharmacokinetics in healthy male adults. 48 healthy male volunteers, aged 23 to 47 years old, weighing 53 ~ 79kg, height 162 ~ 185cm. First of all,