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Forskolin是从毛喉鞘蕊花提取的有生物活性的双萜化合物,它的药理特性是能强效增强不同动物的心肌收缩力和降低血压,特别用于静注。它的药理特性归因于它能直接刺激作用于腺苷酸环化酶系统的催化单位。临床研究表明用于治疗青光眼、慢性梗塞性肺病和充血性心力衰竭有发展前途。由于它的溶解度差,限制了生物研究。为了克服此缺点,合成了forskolin衍生物8,13-环氧-6β-(哌啶乙酰氧基)-1α,7β,9α-三羟基-labd-14-烯-11-酮(HL706),体外和体内实验表明,它有明显的增强心肌收缩力,增加心率和降低平均血压的作用。虽然它的作用强度低于
Forskolin is a biologically active diterpene compound extracted from Coiliaceae and its pharmacological properties are powerful in enhancing myocardial contractility and lowering blood pressure in different animals, especially for intravenous injection. Its pharmacological properties are attributed to its ability to directly stimulate catalytic units acting on the adenylate cyclase system. Clinical studies have shown promise for the treatment of glaucoma, chronic obstructive pulmonary disease and congestive heart failure. Due to its poor solubility, biological research is limited. In order to overcome this disadvantage, forskolin derivatives 8,13-epoxy-6β- (piperidineacetoxy) -1α, 7β, 9α-trihydroxy-labd-14-en- 11-one (HL706) And in vivo experiments show that it has significantly enhanced myocardial contractility, increase heart rate and reduce the average blood pressure. Although its effect intensity is lower than