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[目的]观察胃肠安丸对小儿轮状病毒(RV)肠炎患者心肌损伤的保护作用,以及其相关的临床疗效。[方法]选择我院儿科2012年12月~2014年12月治疗的轮状病毒肠炎患儿160例,随机分为对照组和胃肠安丸治疗观察组,每组各80例,比较2组治疗前后心肌酶谱的变化以及临床疗效。[结果]观察组平均腹泻和退热时间为(42.46±7.34)h和(27.25±4.43)h,对照组平均腹泻和退热时间为(57.36±8.52)h和(36.82±5.13)h,上述指标在2组之间差异有统计学意义(P<0.05)。对照组临床治疗有效率为75.0%,显著低于观察组的91.2%(P<0.05)。2组治疗后LDH、CK和CK-MB心肌酶谱指标均出现显著减低(P<0.05、P<0.01),但观察组对LDH、CK和CK-MB的改善程度显著优于对照组(P<0.05)。[结论]胃肠安丸可以保护RV的心肌损伤,提高RV肠炎患儿的临床疗效,具有一定的临床应用价值。
[Objective] To observe the protective effect of weiaosanan on myocardial injury in children with rotavirus (RV) enteritis and its related clinical effects. [Methods] A total of 160 children with rotavirus enteritis who were treated in our hospital from December 2012 to December 2014 were randomly divided into control group and Weishangan pill treatment group, with 80 cases in each group. The treatment of two groups were compared Changes in myocardial enzymes before and after as well as clinical efficacy. [Results] The mean diarrhea and antipyretic time in the observation group were (42.46 ± 7.34) h and (27.25 ± 4.43) h, respectively. The average diarrhea and antipyretic time in the control group were (57.36 ± 8.52) h and (36.82 ± 5.13) The difference between the two groups was statistically significant (P <0.05). The effective rate of clinical treatment in the control group was 75.0%, which was significantly lower than that in the observation group (91.2%, P <0.05). The myocardial enzymes of LDH, CK and CK-MB in both groups were significantly decreased (P <0.05, P <0.01), but the improvement of LDH, CK and CK-MB in the observation group was significantly better than that in the control group <0.05). [Conclusion] Weizuo’an Pill can protect the myocardial injury of RV and improve the clinical curative effect of children with RV enteritis, which has a certain clinical value.