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铁碳纳米粒分为铁碳纳米复合微粒和碳包铁纳米粒两类,可以通过机械研磨法、碳弧法、气相沉积法、热解法、爆炸法等方法制备。铁碳纳米粒具有较好的吸附作用和磁效应,是较为理想的化疗药物载体,用于搭载多柔比星、丝裂霉素、卡铂等化疗药物。铁碳纳米药物复合体具有载药量高、释放性能稳定的特点,能够维持抑制肿瘤细胞增殖的足够浓度,并有明显的靶器官聚集趋势,对靶器官以外组织的毒性作用大为降低;除此之外,铁碳纳米粒还具有磁感应发热效能,其发热效应跟磁性粒子的数量、浓度、感应电场作用时间有关,对肿瘤具有热杀伤作用。铁碳纳米粒作为药物载体抗肿瘤的研究在体内外实验中取得了重大进展,相信不久的将来,在临床肿瘤治疗中显示出良好的使用价值。
Iron-carbon nanoparticles are classified into two categories: iron-carbon nanocomposite particles and carbon-coated nanoparticles, which can be prepared by mechanical milling, carbon arc, vapor deposition, pyrolysis, explosion and other methods. Iron-carbon nanoparticles with good adsorption and magnetic effects, is the ideal carrier of chemotherapy drugs, used to carry doxorubicin, mitomycin, carboplatin and other chemotherapy drugs. Iron-carbon nano-drug complex with high drug loading, stable release characteristics, can maintain a sufficient concentration of inhibition of tumor cell proliferation, and there is a clear trend of target organ accumulation, target organ toxicity outside the organization greatly reduced; except In addition, the iron-carbon nanoparticles also have the magnetic induction heating efficacy, the heating effect with the number of magnetic particles, concentration, the role of induction time of the electric field, the tumor has a thermal effect. Iron-carbon nanoparticles as a drug carrier antitumor research in vivo and in vitro experiments have made significant progress, I believe in the near future, the clinical tumor treatment showed good value.