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苯二氮(?)(BDZ)类药物是临床广泛使用的抗焦虑药。大量证据表明,这类药物的效应是通过体内BDZ受体中介产生的。BDZ和吗啡均为机体的外源性物质;自从体内发现阿片受体后,又发现了阿片受体的内源性配体阿片肽及非肽类吗啡样物质。在发现BDZ受体的同时,人们就开始寻找可能存在的BDZ受体内源性配体。先后在多种组织提取物中发现嘌呤,嘌呤核苷酸、烟酰胺,以及一些肽和分子量在1500至70000的蛋白质可与BDZ受体结合,但未见它们具有与BDZ相似或相反的药理效应。1980年从人尿中分离出β-卡
Benzodiazepine (?) (BDZ) drugs are widely used in clinical anti-anxiety drugs. There is ample evidence that the effect of these drugs is mediated through the BDZ receptor in vivo. Both BDZ and morphine are exogenous substances in the body. Since the discovery of opioid receptors in vivo, opioid peptides, non-peptide morphine-like substances, have also been found. At the same time as BDZ receptors were found, people began to search for possible endogenous BDZ receptor ligands. Purine, purine nucleotides, nicotinamide, and some peptides and proteins with molecular weights between 1500 and 70000 have been found in various tissue extracts to bind to BDZ receptors, but they have not been found to have similar or opposite pharmacological effects as BDZ . In 1980, β-card was isolated from human urine