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目的:探讨甲状腺乳头状癌雌激素受体阳性表达的临床病理意义。方法:应用免疫组化SP法对80例甲状腺乳头状癌,30例滤泡状癌及50例癌旁正常甲状腺组织雌激素受体(ER)进行测定。结果:甲状腺乳头状癌、滤泡状癌及正常组织ER阳性率分别为67.50%(54/80)、23.33%(7/30)及6%(3/50);乳头状癌ER阳性率显著高于滤泡状癌及正常组织;乳头状癌中原发癌ER阳性率显著高于复发癌,无淋巴结转移者ER阳性率显著高于有淋巴结转移者,女性ER阳性率显著高于男性。结论:甲状腺乳头状癌ER阳性率显著高于滤泡状癌及正常组织甲状腺乳头状癌的发生与雌激素关系密切,检测其ER有助于指导治疗。
Objective: To investigate the clinicopathological significance of estrogen receptor positive expression in thyroid papillary carcinoma. METHODS: Immunohistochemical SP method was used to detect estrogen receptor (ER) in 80 cases of papillary thyroid carcinoma, 30 cases of follicular carcinoma, and 50 cases of normal thyroid tissue around the tumor. Results: The positive rate of ER in papillary thyroid carcinoma, follicular carcinoma, and normal tissues were 67.50% (54/80), 23.33% (7/30), and 6% (3/50), respectively. The positive rate of ER in papillary carcinoma was significant. It was higher than follicular carcinoma and normal tissue. The positive rate of ER in primary carcinoma was significantly higher than that in recurrent carcinoma. The positive rate of ER in patients without lymph node metastasis was significantly higher than those with lymph node metastasis. The positive rate of female ER was significantly higher than that of male. Conclusion: The positive rate of ER in papillary thyroid carcinoma is significantly higher than that in follicular and normal papillary thyroid carcinoma. Estrogen is closely related to the occurrence of ER in thyroid papillary carcinoma. Detection of ER may be helpful in guiding treatment.