[Objective]To optimize the refined Tianma Gouteng Decoction by AB-8 macroporous resin.[Method]With gastrodin content and pasteforming rate as the indices,the maximum sample volume,sample injection flow,eluent concentration and other factors were optimized during the purification process by single factor test and orthogonal test.[Result] The average paste-forming rate was 21.252 7% before resin purification process and RSD was 1.009 6%;the average gastrodin content was 5.263 mg /g and RSD was 0.693%.The optimal process was as follows:30 ml maximum sample volume,2 BV /h sample injection flow,40% ethanol as eluent,165 ml eluent dosage,0.5 g /ml medical solution,and 1:10 diameter-height ratio.Under this condition,the dry extract rate was 9.98% and the average content of gastrodin was 13.364 mg /g.[Conclusion] This method was reasonable and feasible,could enhance the content of gastrodin,and reduce the extracts amount. [Objective] To optimize the refined Tianma Gouteng Decoction by AB-8 macroporous resin. [Method] With gastrodin content and pasteforming rate as the indices, the maximum sample volume, sample injection flow, eluent concentration and other factors were optimized during the purification process by single factor test and orthogonal test. The average paste-forming rate was 21.252 7% before resin purification process and RSD was 1.009 6%; the average gastrodin content was 5.263 mg / g and RSD was 0.693%. The optimal process was as follows: 30 ml maximum sample volume, 2 BV / h sample injection flow, 40% ethanol as eluent, 165 ml eluent dosage, 0.5 g / ml medical solution, and 1:10 diameter-height ratio. dry extract rate was 9.98% and the average content of gastrodin was 13.364 mg / g. [Confclusion] This method was reasonable and feasible, could enhance the content of gastrodin, and reduce the extracts amount.