1979年12月在日本Sapporo一所孤儿院爆发一次非细菌性胃肠炎。54名1～23月龄的婴儿中43名受到感染,40名有腹泻,其中11名伴有呕吐;另3名仅有呕吐。有些婴儿伴有发热和咳嗽,腹泻1～9天,平均3天。35份患儿的粪液标本用直接电镜检测,其中17份(48.6%)检出一种33～39nm的病毒样颗粒,暂定名为Sapporo因子。 In December 1979, a non-bacterial gastroenteritis broke out in an orphanage in Sapporo, Japan. Forty-four infants aged 1 to 23 months were infected with 43 and 40 with diarrhea, of whom 11 were vomited and the other 3 were only vomiting. Some babies with fever and cough, diarrhea 1 to 9 days, an average of 3 days. Semen specimens of 35 children were examined by direct electron microscopy. Among them, 17 (48.6%) detected 33-39 nm virus-like particles, tentatively named Sapporo factor.