目的探讨随结直肠息肉恶性度增加结直肠变异结肠腺窝病灶的变化。方法在结肠内镜检查中,发现息肉后对息肉病灶进行活检,活检组织作病理学检查,同时,对直肠、结肠远端10cm黏膜进行靓胭脂染色,计数变异结肠腺窝病灶的数量。结果炎性息肉、管状腺瘤、绒毛状腺瘤及腺癌间ACF数量的差异具有统计学意义。结论本实验结果显示变异结肠腺窝病灶可作为结直肠息肉恶性度的生物标志。 Objective To investigate the changes of colonic crypt foci in colorectal lesions with the increase of malignancy of colorectal polyps. Methods In the colon endoscopy, polyp lesions were biopsied after polyp was found. Biopsy tissues were examined by biopsy. At the same time, 10cm mucosa of the rectum and colon were stained with Rouge and the number of colonic fossa lesions was counted. Results There was a significant difference in the number of ACF between inflammatory polyps, tubular adenoma, villous adenoma and adenocarcinoma. Conclusion The results of this experiment show that the variation of colonic crypt lesions can be used as a biomarker of colorectal polyp malignancy.