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对16例未经化疗的GTT患者、15例正常妇女、11例GTT痊愈妇女、14例GTT痊愈妇女再生育子女及12例正常儿童的外周血染色体畸变率及脆性部位进行了观察。结果表明,GTT患者的染色体畸变率、脆性部位表达均明显高于对照组(P<0.01)。化疗痊愈妇女及其子女的染色体畸变和脆性部位表达均与对照组无区别。
Chromosome aberration rates and fragile sites in peripheral blood of 16 untreated GTT patients, 15 normal women, 11 GTT-cured women, 14 GTT-recuperating women and 12 normal children were observed. The results showed that the chromosome aberration rate and the expression of fragile parts of GTT patients were significantly higher than that of the control group (P <0.01). Chromosome aberrations and fragile parts of women and their children who were cured by chemotherapy had no difference with the control group.