论文部分内容阅读
目的:探讨血清血管内皮生长因子水平在肺癌诊断和预后中的临床意义。方法:采用ELISA法对49例肺癌患者及20例健康体检者的血清血管内皮生长因子分别进行测定,同时用化学发光法测定肺癌患者血清癌胚抗原的含量。结果:肺癌患者血清血管内皮生长因子水平明显高于健康对照组(P<0.01),肺癌患者血清血管内皮生长因子水平与其生存期之间呈负相关(P<0.01)。血清血管内皮生长因子对肺癌诊断的灵敏度为85.71%,特异度为70%。血清癌胚抗原、血管内皮生长因子及联合检测的阳性率分别为51.02%,85.71%,91.84%,血管内皮生长因子阳性率明显高于血清癌胚抗原。结论:血清血管内皮生长因子是一种良好的肿瘤标记物,对肺癌的诊断和评估预后具有重要的临床价值,其诊断价值优于血清癌胚抗原。
Objective: To investigate the clinical significance of serum vascular endothelial growth factor in the diagnosis and prognosis of lung cancer. Methods: The serum levels of vascular endothelial growth factor (VEGF) in 49 patients with lung cancer and 20 healthy individuals were determined by ELISA. The levels of serum carcinoembryonic antigen in patients with lung cancer were determined by chemiluminescence. Results: The levels of serum vascular endothelial growth factor in lung cancer patients were significantly higher than those in healthy controls (P <0.01). The levels of serum vascular endothelial growth factor in lung cancer patients were negatively correlated with their survival time (P <0.01). The sensitivity of serum vascular endothelial growth factor in the diagnosis of lung cancer was 85.71% and the specificity was 70%. The positive rates of serum carcinoembryonic antigen, vascular endothelial growth factor and combined detection were 51.02%, 85.71% and 91.84%, respectively. The positive rate of VEGF was significantly higher than that of serum carcinoembryonic antigen. Conclusion: Serum vascular endothelial growth factor is a good tumor marker. It has important clinical value in the diagnosis and prognosis of lung cancer, and its diagnostic value is better than that of serum carcinoembryonic antigen.