慢性髓细胞白血病(CML)是多能干细胞的克隆性疾病。它具有特征性的染色体 t(9;22)(q34;q11)易位,形成 Ph 染色体。许多研究表明,CML 的自然病程涉及骨髓网硬蛋白进行性的堆积,尽管进展的速度各不相同。推测骨髓重度纤维化和 CML 的加速期或急变期的发展密切相关,两者都与预后差有关。另外,骨髓纤维化引起骨髓衰竭并发症,可能对骨髓移植 Chronic myeloid leukemia (CML) is a clonal disease of pluripotent stem cells. It has a characteristic chromosome t(9;22)(q34;q11) translocation that forms the Ph chromosome. Many studies have shown that the natural course of CML involves the progressive accumulation of myelin, although the rate of progression varies. It is speculated that severe fibrosis of bone marrow is closely related to the development of the accelerated or blastic phase of CML, both of which are associated with poor prognosis. In addition, bone marrow fibrosis causes complications of bone marrow failure, possibly for bone marrow transplantation.