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生物化学研究方面:我们研究了橘霉素的制菌作用,金霉素的抗生作用和鏈霉素对于链霉素依赖性的大肠杆菌作用的机制。关于橘霉素的抗生作用方式,曾研究了橘霉素对于动物組織细胞、金色葡萄球菌和大肠杆菌的呼吸作用及对于細胞酶的作用,并証明了琥珀酸氧化酶系对于橘霉素最为敏感。抑制的主要对象可能是琥珀酸氧化酶系的“中間联系因素”。关于金霉素的抗生作用机制,我們的研究結果指出,金霉素抑制了氮的氧化同化。目前我們在研究:1.金霉素对于貧氮大肠杆菌从氨产生核酸与蛋白
Biochemical research: We studied the bacteriostasis of citrinin, the antibacterial effect of chlortetracycline, and the mechanism of streptomycin on streptomycin-dependent Escherichia coli. On the antibacterial effect of citrinin, we studied the respiration of citrulline against animal tissue cells, Staphylococcus aureus and Escherichia coli and its effect on cellular enzymes and demonstrated that succinate oxidase is the most sensitive to citrinin . The main target of inhibition may be “intermediate contact factor” of succinate oxidase system. On the antibacterial mechanism of chlortetracycline, our results indicate that chlortetracycline inhibits nitrogen oxidation and assimilation. Currently we are studying: 1. Chlortetracycline for ammonia-depleted Escherichia coli produce nucleic acids and proteins from ammonia