在老年人,胃食管返流性疾病较常见。许多保护机制如食管一级蠕动、食管碳酸氢盐的分泌以及唾液的分泌均随年龄增长而改变,因此老年人更易患较严重的胃食管返流性疾病。 方法 228例病人因灼热症状作过内镜及基础排酸量检查诊断为胃食管返流病。其中98例仅有胃灼热,87例有糜烂性食管炎,43例有Barrett食管。治疗前测基础酸分泌量,然后予雷尼替丁150mg,q 12h口服8～12周。嘱每月随访,若症状消失,3～9月内复查内镜。期 In the elderly, gastroesophageal reflux disease is more common. Many protective mechanisms such as esophageal peristalsis, esophageal bicarbonate secretion, and salivary secretion change with age, so the elderly are more susceptible to severe gastroesophageal reflux disease. Methods A total of 228 patients were diagnosed with gastroesophageal reflux disease by endoscopy and basal acid excretion examination. 98 of them had heartburn only, 87 had erosive esophagitis, and 43 had Barrett’s esophagus. Pretreatment baseline acid secretion, and then to ranitidine 150mg, q 12h oral 8 to 12 weeks. Zhu ordered monthly follow-up, if the symptoms disappear, 3 to 9 months review endoscopy. period