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目的观察中医药治疗手足口病(HFMD)普通型的临床疗效。方法将636例HFMD患者随机分为治疗组和对照组,治疗组180例给予清热解毒化湿中医药治疗,对照组456例给予抗病毒药、抗生素和激素等西医药治疗。观察2组治疗前后临床症状、体征变化和疗效,评价单纯中医药疗法的疗效。结果治疗组总有效率(100.0%)、疹退时间〔(5.50±1.34)d〕、口腔黏膜疹治疗前后积分差值〔(3.74±1.35)分〕,与对照组〔98.7%,(5.45±1.06)d、(3.52±0.87)分〕比较差异无统计学意义(P均>0.05);2组分别有112、325例患儿发热,治疗组退热时间显著短于对照组〔(1.79±1.03)vs(3.08±0.97)d,P<0.05〕。结论清热解毒化湿中药对于HFMD普通型临床疗效可靠,而且有明显的退热、促进疱疹和(或)皮疹消退、减轻咽痛、缩短病程等综合效应。
Objective To observe the clinical efficacy of traditional Chinese medicine in the treatment of common hand-foot-mouth disease (HFMD). Methods A total of 636 HFMD patients were randomly divided into treatment group and control group. 180 cases in the treatment group were treated with Qingrejiedu Huashi Chinese medicine, and 456 in the control group were treated with western medicine such as antiviral drugs, antibiotics and hormones. The clinical symptoms, signs and symptoms before and after treatment were observed in two groups, and the curative effect of simple Chinese medicine therapy was evaluated. Results The total effective rate was 100.0% in the treatment group (5.50 ± 1.34 d), the integral difference before and after oral mucosal rash 〔(3.74 ± 1.35) points〕, compared with the control group 〔98.7%, (5.45 ± 1.06) d, (3.52 ± 0.87) points, respectively (P> 0.05). There were 112,325 children with fever in the two groups, and the fever time in the treatment group was significantly shorter than that in the control group 〔(1.79 ± 1.03) vs (3.08 ± 0.97) d, P <0.05〕. Conclusion The detoxification and dampness Chinese herbal medicine has a reliable clinical effect on HFMD common type, and has obvious antipyretic effects, which can promote herpes and / or rash subsidence, reduce sore throat and shorten the course of disease.