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肿瘤生长与转移依赖于血管生长。肾癌（ＲＣＣ）以血管丰富为特性。血管生长因子直接或间接地刺激宿主的免疫细胞或基质细胞，促进内皮细胞的增殖与迁移，最终导致血管生长，尤其血管内皮生长因子（Ｖａｓｃｕｌａｒ ｅｎｄｏｔｈｅｌｉａｌ ｆａｃｔｏｒ ，ＶＥ ＧＦ）。而
Tumor growth and metastasis depend on the growth of blood vessels. RCC is characterized by vascularity. Vascular growth factors directly or indirectly stimulate the immune cells or stromal cells of the host and promote the proliferation and migration of endothelial cells, eventually leading to the growth of blood vessels, especially Vascular Endothelial Growth Factor (VEGF). and