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目的 :为研究慢性肾功能不全 (CRF)时甲状腺激素的变化及其临床意义。方法 :应用放射免疫法 (RIA)检测 47例CRF患者 ,2 1例肾功能正常的肾脏疾病患者和 2 4例正常人 T3、T4、FT3、FT4、TSH。结果 :CRF患者血清 T3、T4、FT3、FT4明显降低 (P<0 .0 5 ,P<0 .0 1) ,并与 Scr呈显著负相关 (P<0 .0 5 ,P<0 .0 1)。结论 :CRF病例存在继发性甲状腺功能减退症 ,甲状腺激素可作为判定肾功能受损程度的参考指标。
Objective: To investigate the changes of thyroid hormones in patients with chronic renal failure (CRF) and its clinical significance. Methods: 47 patients with CRF, 21 patients with normal renal function, and T4, T4, FT3, FT4 and TSH were detected by radioimmunoassay (RIA). Results: The serum levels of T3, T4, FT3 and FT4 in patients with CRF were significantly lower (P <0.05, P <0.01) and significantly negatively correlated with Scr (P <0.05, P <0. 0 1). Conclusion: There is secondary hypothyroidism in CRF cases. Thyroid hormone can be used as a reference index to judge the extent of renal dysfunction.