血管紧张素转化酶抑制剂(ACEI)能阻断血管紧张素Ⅰ转化为有升压作用的血管紧张素Ⅱ。此转化酶亦为激肽酶,负有清除血管扩张剂缓激肽的作用。 ACEI ACEI阻断血管紧张素Ⅱ的产生,导致了血管扩张。对高血压患者,其典型的血液动力学反应,包括大循环血管阻力下降及大循环动脉压下降。充血性心力衰竭患者的大循环血管阻力和左心室充盈压力下降,心输出量增加,而心率常无变化或略为减慢。ACEI的效果可借助外源性血管紧张素Ⅰ对升压反应抑制的测定,或血浆肾素和转化酶活性的测定,或肾素 Angiotensin converting enzyme inhibitors (ACEIs) block the conversion of angiotensin I to a booster of angiotensin II. This convertase is also a kininase, which has the effect of clearing the vasodilator bradykinin. ACEI ACEI blocks angiotensin II production, leading to vasodilation. For hypertensive patients, the typical hemodynamic response, including the decline in circulatory vascular resistance and decreased circulatory aortic pressure. Circulatory vascular resistance and left ventricular filling pressure decreased in patients with congestive heart failure, cardiac output increased, while heart rate often no change or slightly slowed down. The effect of ACEI can be measured exogenously by angiotensin I inhibition of the step-up response, or determination of plasma renin and invertase activity, or renin