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研究了 1,6 -二磷酸果糖 (FDP)对一次性游泳大鼠心肌组织磷酸果糖激酶 (PFK)、丙酮酸激酶 (PK)、超氧化物歧化酶 (SOD)、Na+、K+-ATP酶的活性 ,MDA含量及血浆中谷草转氨酶 (GOT)、肌酸激酶 (CK)和血乳酸含量 ,以探讨FDP对大强度运动大鼠心肌组织的代谢和细胞膜稳定性的作用。和对照组相比 ,服用FDP使大鼠安静时心肌PFK活性明显升高 ,运动中PFK维持在较高水平 ,PK活性无明显变化 ,Na+、K+-ATP酶活性明显升高 ,运动时心肌组织丙二醛 (MDA)含量增加的幅度下降 ,SOD活性无明显变化 ,安静时血浆CK活性降低 ,运动后血浆GOT和CK活性降低 ,服用FDP可使PFK活性升高更快 ,血浆中GOT和CK恢复加快。结果显示 ,FDP能促进心肌组织糖酵解代谢 ,对运动大鼠心肌细胞膜有一定保护作用 ,能够促进运动后心肌细胞膜功能的恢复。
The effects of fructose 1,6 - diphosphate (FDP) on the phospholipid kinase (PFK), pyruvate kinase (PK), superoxide dismutase (SOD), Na +, K + -ATPase Activity, MDA content and plasma aspartate aminotransferase (GOT), creatine kinase (CK) and blood lactate content in order to investigate the effect of FDP on myocardial metabolism and cell membrane stability in rats with high-intensity exercise. Compared with the control group, PFK activity was significantly increased in rats with resting FDP, PFK in exercise was maintained at a high level, PK activity did not change significantly, Na +, K + -ATP enzyme activity was significantly increased, exercise myocardial tissue The increase of MDA content decreased and the activity of SOD did not change obviously. The activity of plasma CK decreased at rest, the activity of GOT and CK decreased after exercise. FDP increased the activity of PFK in plasma, Recovery accelerated. The results showed that FDP can promote myocardial glycolysis metabolism, myocardial cell membrane of exercise rats have a protective effect, can promote the recovery of myocardial cell membrane after exercise.