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重症肌无力是一种神经肌肉传导方面的疾患。其病因是由于患者的乙酰胆碱受体(Ach R)被自身抗体损害,致使介质(乙酰胆碱)减少或作用改变所致。抗胆碱酯酶类药物,能使介质水解过程减慢,达到改善症状的目的,但病情严重者其疗效很有限。应用皮质激素能使90%的患者症状改善。但即使采用大剂量静脉注射,这种改善要在用药后平均第10天才能见效,第20天才能达到最大效果。且这种改善在病情严重的患者也很有限。反复使用血浆置换术能在第3天见效,第16天达到最大效果,但这种改善一般比较短暂。应用免疫抑制剂或进行胸腺切除治疗,要数月或数年才能见效。本文报道静脉注射大剂量免疫球蛋白(Sando-
Myasthenia gravis is a disorder of neuromuscular transmission. The etiology is due to the patient’s acetylcholine receptor (AchR) is autoantibody damage, resulting in decreased media (acetylcholine) or the role of change. Anticholinesterase drugs, media hydrolysis process can slow down to achieve the purpose of improving symptoms, but the condition is serious, its efficacy is limited. The application of corticosteroids can improve symptoms in 90% of patients. However, even with high-dose intravenous injection, this improvement should be effective in the first 10 days after treatment, the first 20 days to achieve maximum effect. And this improvement is also very limited in patients with serious illness. Repeated use of plasmapheresis can be effective on day 3 and maximum effect on day 16, but this improvement is generally temporary. Immunosuppressive agents or thymectomy treatments take months or years to work. This article reports the intravenous injection of high-dose immunoglobulin (Sando-