脆弱拟杆菌对β -内酰胺和抗厌氧菌的其它抗生素耐药性不断增加 ,因此急需新的治疗厌氧菌感染的有效抗生素。喹诺酮作为单一治疗剂治疗混合感染由于缺乏抗厌氧病原菌的活性而受到限制 ,目前临床主要使用的喹诺酮环丙沙星、氧氟沙星、左氧氟沙星和司帕沙星均在体外对厌氧菌活性 The resistance of Bacteroides fragilis to other antibiotics of β-lactam and anti-anaerobic bacteria is increasing, so there is an urgent need for new effective antibiotics for treating anaerobic infections. Quinolone as a monotherapy for the treatment of mixed infections due to the lack of anti-anaerobic pathogens activity is limited, the main clinical use of quinolone ciprofloxacin, ofloxacin, levofloxacin and sparfloxacin in vitro anaerobic activity