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摘自《医学参考报营养学频道》2014年8月第8期期【据《Am J Clin Nutr》2014年8月报道】题:血清植物甾醇、胆甾烷醇、胆固醇的前体物与小儿肠衰竭引起的肝组织损伤相关(作者Mutanen A等)肠功能衰竭(intestinal failure,IF)的特征是广泛的吸收障碍,需要长期的肠外营养(parenteral nutrtion,PN)支持。对肠衰竭患者长期的PN干预往往会引起肠衰竭相关的肝疾病(intestinal failure associated liver disease,IFALD)。IFALD是患者死亡的主要原因,尤其是婴幼儿。虽然已知有多种因素导致IFALD,包括PN的成分和持续时间,其确切的病理生理
From “Medical Reference Daily Nutrition Channel” Issue 8, August 2014 [As reported by Am J Clin Nutr in August 2014] Title: Serum Phytosterols, Cholesterol, Cholesterol Precursors and Pediatric Intestines Depletion-Induced Liver Tissue Injury (Authors Mutanen A et al.) Intestinal failure (IF) is characterized by extensive malabsorption and requires long-term parenteral nutrtion (PN) support. Long-term PN intervention in patients with intestinal failure often leads to intestinal failure associated liver disease (IFALD). IFALD is the main cause of death in patients, especially infants and young children. Although a number of factors are known to cause the composition and duration of IFALD, including PN, its exact pathophysiology