论文部分内容阅读
目的探索围绝经期女性血清雌二醇(E2)、卵泡刺激素(FSH)变化规律与其腰椎、髋部、股骨颈骨密度(BMD)的关系。方法选取2014年1月-2015年1月在该院进行体检的围绝经期妇女440例为研究对象,分为绝经前组(220例)和绝经后组(220例)。测定两组血清E2、FSH水平及其腰椎、髋部、股骨颈BMD值,并进行组间比较。结果绝经后组妇女血清E2与绝经前组比较明显减少,而血清FSH与绝经前组比较明显增加,差异均有统计学意义(P<0.05)。绝经后组妇女腰椎、髋部、股骨颈BMD值与绝经前组比较均有明显减少,组间差异均有统计学意义(P<0.05)。绝经前低骨量组和绝经后低骨量组血清E2水平均较正常骨量组明显减少,而血清FSH水平均较正常骨量组明显增加,差异均有统计学意义(P<0.05)。血清E2水平与腰椎BMD、髋部BMD、股骨颈BMD均呈正相关关系(P<0.05);血清FSH水平与腰椎BMD、髋部BMD、股骨颈BMD均呈负相关关系(P<0.05)。结论绝经后女性BMD明显减少,雌激素水平变化可能影响骨代谢,应引起临床的高度关注。
Objective To explore the relationship between the changes of serum estradiol (E2), follicle stimulating hormone (FSH) and lumbar spine, hip and femoral neck bone mineral density (BMD) in perimenopausal women. METHODS: Forty-four perimenopausal women undergoing physical examinations in our hospital from January 2014 to January 2015 were selected as the study subjects and divided into premenopausal group (220 cases) and postmenopausal group (220 cases). Serum E2, FSH levels and BMD of lumbar, hip and femoral neck were measured and compared between two groups. Results Serum E2 of postmenopausal women was significantly decreased compared with premenopausal women, while serum FSH was significantly increased compared with premenopausal women (P <0.05). The BMD of lumbar spine, hip and femoral neck in postmenopausal women were significantly decreased compared with those in premenopausal women. The differences between the two groups were statistically significant (P <0.05). Pre-menopausal low bone mass group and postmenopausal low bone mass group serum E2 levels were significantly lower than the normal bone mass group, while serum FSH levels were significantly increased compared with the normal bone mass group, the difference was statistically significant (P <0.05). Serum E2 level was positively correlated with BMD of lumbar spine, hip BMD and femoral neck BMD (P <0.05). Serum FSH level was negatively correlated with BMD of lumbar spine, hip BMD and BMD of femoral neck (P <0.05). Conclusion The postmenopausal women with BMD decreased significantly, and the changes of estrogen levels may affect bone metabolism, which should arouse clinical attention.