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了解慢性肝炎患者血清中细胞外间质（ＥＣＭ）成分透明质酸（ＨＡ）、层粘连蛋白（ＬＮ）、Ⅳ型胶原（ⅣＣ）的水平，探讨它们和甲胎蛋白（ＡＦＰ）的关系。方法用放射免疫方法测定１１３例患者血清中ＨＡ、ＬＮ、ⅣＣ、ＡＦＰ的含量。结果慢性肝炎患者ＨＡ、ＬＮ、ⅣＣ、ＡＦＰ的血清含量均数（除轻度组ＬＮ外）与正常对照组有显著差异（Ｐ＜０．０５）。在慢性肝炎轻度组３种细胞外间质成分中ⅣＣ的阳性率最高，并且其含量与ＡＦＰ的水平呈正相关（Ｐ＜０．０１）。结论血清ⅣＣ是反映早期肝纤维化的敏感指标，其血清水平与肝细胞胶原代谢及分泌ＡＦＰ有一定关系
To investigate the levels of extracellular matrix (ECM), hyaluronic acid (HA), laminin (LN) and collagen Ⅳ (ⅣC) in serum of patients with chronic hepatitis, and to explore their relationship with AFP. Methods The serum levels of HA, LN, Ⅳ C and AFP in 113 patients were determined by radioimmunoassay. Results The mean serum levels of HA, LN, Ⅳ C and AFP in patients with chronic hepatitis (except mild LN) were significantly different from those in normal controls (P <0.05). The positive rate of ⅣC was the highest among the three extracellular components of mild chronic hepatitis group, and the positive rate of ⅣC was positively correlated with the level of AFP (P <0.01). Conclusions Serum ⅣC is a sensitive indicator of early liver fibrosis. The serum level of ⅣC is related to collagen metabolism and secretion of AFP in hepatocytes