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目的 :研究丹奥 (注射用奥扎格雷钠 )治疗急性脑梗塞 46例的疗效。方法 :用丹奥静滴治疗急性脑梗塞 46例 ,用维脑路通静滴作为对照治疗 40例 ,比较入院当日和治疗 15天时的神经功能缺损评分。随机抽取观察组、对照组各 2 0例通过CBA测定颈总动脉血流流速最小值Vmin于治疗前后测定比较。结果 :神经功能缺损评分观察组治疗前 19.2± 8.5 ,治疗后为 10 .1± 7.6 ;对照组治疗前 18.7± 8.3,治疗后为 14.5± 6 .2。治疗后观察组明显优于对照组 (P <0 .0 1)。治疗前观察组和对照组Vmin分别为 3.1± 1.2和 3 .3± 1.1,治疗后分别为 10 .7± 3 .1和 7.4± 2 .6。两者比较显著差异 (P <0 .0 1)。结论 :丹奥治疗急性脑梗塞较传统的基础药物治疗后神经功能缺损评分明显减少 ,Vmin值上升亦明显。
Objective: To study the efficacy of Danio (sodium ozagrel for injection) in the treatment of 46 cases of acute cerebral infarction. Methods: 46 cases of acute cerebral infarction were treated with intravenous infusion of Danio, 40 cases were treated with intravenous drip of Venoruton as control, and the neurological deficit scores were compared between the day of admission and the 15th day of treatment. The observation group and the control group were randomly selected for the determination of the common carotid artery flow velocity Vmin by CBA in 20 cases before and after treatment comparison. Results: The score of neurological deficit in observation group before treatment was 19.2 ± 8.5, after treatment was 10 .1 ± 7.6; in control group before treatment was 18.7 ± 8.3, after treatment was 14.5 ± 6 .2. After treatment, the observation group was significantly better than the control group (P <0.01). The Vmin of the observation group and the control group before treatment were 3.1 ± 1.2 and 3.3 ± 1.1, respectively, and were 10.7 ± 3.1 and 7.4 ± 2,6 after treatment respectively. The difference between the two was significant (P <0.01). Conclusion: Danio treatment of acute cerebral infarction compared with the traditional basic medicines significantly reduced neurological deficit score, Vmin value increased significantly.