高脂血症为肾病综合征的特征之一，以往认为是继发性改变，自从1982年Moorhead[1]率先指出脂蛋白可能有潜在肾毒性后，高脂血症所致的肾小球损伤尤为使人关注，国内对此报道较少，现将我们的研究结果报告如下。材料与方法一、材料Wistar大鼠购于河南省实验动物中心；阿霉素注射 Hyperlipidemia is one of the characteristics of nephrotic syndrome, previously considered a secondary change, since 1982, Moorhead [1] first pointed out the potential nephrotoxicity of lipoprotein, hyperlipidemia-induced glomerular injury In particular, people are concerned about this report less domestic, the results of our research are reported as follows. Materials and Methods First, the material Wistar rats were purchased from Henan Experimental Animal Center; doxorubicin injection