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为研究肾病综合征（ＮＳ）时抗氧化功能状况，我们测定３６例患者血超氧化物歧化酶（ＳＯＤ）、丙二醛（ＭＤＡ）及维生素Ｅ，以及尿ＳＯＤ、ＭＤＡ。结果表明：ＮＳ患者血总ＳＯＤ、Ｃｕ－Ｚｎ－ＳＯＤ及维生素Ｅ水平明显低于正常对照组（分别为７６．２２±２７．４８μＵ／Ｌ比１０４．２０±１８．８０μＵ／Ｌ，Ｐ＜０．００１；２０．４０±２２．６３μＵ／Ｌ比６２．９９±１５．６０μＵ／Ｌ，Ｐ＜０．００１；６．６８±３．５２ｍｇ／Ｌ比１６．３８±１．０５ｍｇ／Ｌ，Ｐ＜０．００１）；尿ＳＯＤ及ＭＤＡ明显高于对照组（分别为：１１４．９８±３１．７３μＵ／Ｌ比８２．３４±２６．５０μＵ／Ｌ，Ｐ＜０．００１；３．９９±１．９８μｍｏｌ／Ｌ比２．６４±０．７８μｍｏｌ／Ｌ，Ｐ＜０．００１）．研究提示，ＮＳ时抗氧化功能减退，肾脏易遭受氧自由基损害。
To investigate antioxidant status during nephrotic syndrome (NS), we measured serum superoxide dismutase (SOD), malondialdehyde (MDA) and vitamin E, and urinary SOD and MDA in 36 patients. The results showed that the levels of serum total superoxide dismutase, Cu-Zn-SOD and vitamin E in patients with NS were significantly lower than those in the normal control group (76.22 ± 27.48μU / L vs 104.20 ± 18.80μU / L, P <0 .001; 20.40 ± 22.63 μU / L than 62.99 ± 15.60 μU / L, P <0.001; 6.68 ± 3.52 mg / L vs 16.38 ± 1.05 mg / L, P <0.001). Urine SOD and MDA were significantly higher than those in the control group (114.98 ± 31.73μU / L vs 82.34 ± 26.50μU / L, P <0.001; 3.99 ± 1 .98 μmol / L vs. 2.64 ± 0.78 μmol / L, P <0.001). Research suggests that NS anti-oxidative dysfunction, renal vulnerability to oxygen free radicals damage.