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目的研究ｎｍ２３基因表达与食管癌生物学行为和预后的关系。方法应用免疫组织化学ＳＰ法检测７６例食管鳞状细胞癌手术标本中ｎｍ２３表达。结果食管癌原发灶癌组织中ｎｍ２３表达阳性率８１．６％，癌旁形态学正常食管粘膜ｎｍ２３阳性率３６．８％，差异具有显著性意义（Ｐ＜０．００１）；食管癌ｎｍ２３高表达者的区域淋巴结转移发生率（５８．２％）明显高于低表达者（２２．２％，Ｐ＜０．００５）；ｎｍ２３表达水平与癌组织浸润食管深度及食管癌ＴＮＭ分期呈正相关，统计学均具有显著性意义（分别为Ｐ＜０．０５、Ｐ＜０．０２）；ｎｍ２３低表达的患者术后三年和五年生存率分别为６０．０％和５１．６％，显著高于ｎｍ２３高表达者（３８．７％和２２．６％），Ｐ＜０．０５和Ｐ＜０．０１。结论ｎｍ２３基因过度表达与食管鳞状细胞癌的浸润及淋巴结转移有关，是预后不良的指标
Objective To investigate the relationship between nm23 gene expression and biological behavior and prognosis of esophageal cancer. Methods Immunohistochemical SP method was used to detect nm23 expression in surgical specimens of 76 patients with esophageal squamous cell carcinoma. Results The positive rate of nm23 expression was 81.6% in primary tumor tissues of esophageal cancer, and the positive rate of nm23 positive in esophageal mucosa adjacent to tumor was 36.8%. The difference was significant (P<0.001); nm23 high in esophageal cancer The rate of regional lymph node metastasis was significantly higher in the expression group (58.2%) than in the low expression group (22.2%, P<0.005). The nm23 expression level was positively correlated with the infiltrating esophageal depth and the TNM staging of esophageal cancer. Statistically significant (P<0.05, P<0.02, respectively); patients with low nm23 expression had three-year and five-year survival rates of 60.0% and 51.6%, respectively. Higher than those with high nm23 expression (38.7% and 22.6%), P<0.05 and P<0.01. Conclusion The overexpression of nm23 gene is associated with invasion and lymph node metastasis of esophageal squamous cell carcinoma and is an indicator of poor prognosis.