外源基因在目的细胞中高效、稳定的表达是基因治疗获得成功的关键,这在很大程度上取决于基因治疗采用的载体系统。病毒载体因转染效率高,感染细胞广泛,且某些还具有定向整合靶细胞染色体的能力,可使目的基因长效表达[1],在基因治疗的 The efficient and stable expression of foreign genes in the target cells is the key to the success of gene therapy, which depends to a large extent on the vector system used in gene therapy. Due to the high efficiency of transfection, the wide range of infected cells and the ability of some of them to target the integration of the target cell chromosomes, the long-term expression of the target gene can be achieved. In gene therapy