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目的:检测肥胖儿童和正常对照儿童血清瘦素水平,探讨瘦素与体重指数、空腹血糖、胰岛素、胰岛素抵抗指数及血脂等的相关性。方法:对100例肥胖儿童及100例正常对照儿童测量身高、体重,计算体重指数(BMI);检测空腹血糖(FPG)、胰岛素(FINS)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A(ApoA)、载脂蛋白B(ApoB);胰岛素抵抗采用稳态模式评估法的胰岛素抵抗指数(HOMA-IR)指标;血清瘦素采用酶联免疫吸附试验检测。结果:肥胖儿童组血清瘦素显著高于正常对照组儿童(P<0.05);血清瘦素与BMI、ALT、TG、LDL-C、APB、FINS、HOMA呈正相关r,值分别为(0.647,0.5840,.328,0.198,0.314,0.5230,.484,P值均<0.05);与HDL-C呈负相关(r=-0.151,P<0.05)。结论:瘦素作为一种脂肪因子,在儿童肥胖的发生中起重要作用。
OBJECTIVE: To detect serum leptin levels in obese children and normal children and to explore the correlation between leptin and body mass index, fasting blood glucose, insulin, insulin resistance index and blood lipids. Methods: The body weight and weight were measured in 100 obese children and 100 normal children. Body mass index (BMI), fasting blood glucose (FPG), insulin (FINS), total cholesterol (TC), triglyceride HDL-C, LDL-C, ApoA, ApoB; insulin resistance insulin resistance index using steady-state model (HOMA-IR) index; serum leptin using enzyme-linked immunosorbent assay. Results: Serum leptin in obese children was significantly higher than that in normal controls (P <0.05). Serum leptin was positively correlated with BMI, ALT, TG, LDL-C, APB, FINS and HOMA (r = 0.647, 0.5840, .328,0.198,0.314,0.5230, .484, P <0.05), but negatively correlated with HDL-C (r = -0.151, P <0.05). Conclusion: Leptin, an adipokine, plays an important role in the development of childhood obesity.