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应用高效液相色谱法（ＨＰＬＣ）检测４２例正常人，２４例肾功能正常之慢性肾炎，１２例慢性肾炎肾功能不全氮质血症期患者及２１例尿毒症期患者尿ＦＰＡ水平，其均值分别为：２５．４０±１０．３０ｎｇ／ｍｇＣｒ、２６．９９±５．７７ｎｇ／ｍｇＣｒ、３８．８１±６．２８ｎｇ／ｍｇＣｒ、７９．７４±１８．７６ｎｇ／ｍｇＣｒ。结果显示：氮质血症期组尿ＦＰＡ水平明高于正常对照及肾功能正常之慢性肾炎组（Ｐ＜０．０１），尿毒症期组尿ＦＰＡ显著高于氮质血症期组（Ｐ＜０．０１）。监测尿ＦＰＡ水平与血浆肌酐浓度显示二者呈正相关性（ｒ＝０．９１２０，Ｐ＜０．０１）。揭示，慢性肾炎肾功能不全患者循环血液处于异常高凝状态，其严重程度与疾病的发生、发展密切相关，监测其尿ＦＰＡ水平能较敏感地反映肾功能状态。
The levels of urinary FPA in 42 normal subjects, 24 cases of chronic nephritis with normal renal function, 12 cases of chronic nephritis with renal insufficiency azotemia and 21 cases of uremia were detected by high performance liquid chromatography (HPLC) Respectively: 25.40 ± 10.30 ng / mgCr, 26.99 ± 5.77 ng / mgCr, 38.81 ± 6.28 ng / mgCr, 79.74 ± 18.76 ng / mgCr. The results showed that the level of urinary FPA in azotemia group was significantly higher than that in normal control group and chronic nephritis group (P <0.01). Urinary FPA in uremia group was significantly higher than that in azotemia group (P <0.01). Monitoring urine FPA levels and plasma creatinine concentrations showed a positive correlation between the two (r = 0.9120, P <0.01). Revealed that patients with chronic renal failure with renal insufficiency circulating blood abnormal hypercoagulable state, the severity of the disease is closely related to the development of monitoring their urine FPA levels can more sensitive to reflect the renal function status.