以4-硝基苯酚、1-(4-羟基苯基)-1-丙酮为起始原料,经过羟基保护、还原、溴代、BischlerM觟hlau吲哚合成法等反应合成了5-苄氧基-2-(4-苄氧基苯基)-3-甲基-1H-吲哚。该路线原料廉价易得、操作简单、副反应少,收率接近50%,具有较好的应用前景。 4-nitrophenol and 1- (4-hydroxyphenyl) -1-propanone were used as starting materials to synthesize the 5-benzyloxy group through the reaction of hydroxyl protection, reduction, bromination and Bischler Mühlau indole synthesis. -2- (4-benzyloxyphenyl) -3-methyl-1H-indole. The raw materials of the route are cheap and easy to be obtained, the operation is simple, the side reactions are few, the yield is close to 50%, and has good application prospect.