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目的 :探讨慢性乙型肝炎患者血清ICAM - 1、TNF -α和IL - 8水平与肝损害的关系。方法 :应用双抗体夹心酶联免疫吸附法 (ELISA)检测 6 1例慢性乙型肝炎患者血清可溶性细胞间粘附分子 - 1(sICAM - 1)、肿瘤坏死因子 (TNF -α)和白细胞介素 - 8(IL - 8)水平。结果 :慢性乙型肝炎患者血清ICAM - 1、TNF -α和IL - 8水平均明显高于对照组 (P <0 .0 1) ,且病情越重其升高越明显。结论 :慢性乙型肝炎患者血清ICAM -1、TNF -α和IL - 8水平可反映其肝损害程度。检测慢性乙型肝炎患者血清ICAM - 1、TNF -α和IL - 8水平对判断患者病情和预后有一定临床实用价值
Objective: To investigate the relationship between serum levels of ICAM - 1, TNF - α and IL - 8 and liver damage in patients with chronic. Methods: Serum levels of soluble intercellular adhesion molecule - 1 (sICAM - 1), tumor necrosis factor (TNF - α) and interleukin (IL) were measured in 61 patients with chronic hepatitis B by double antibody sandwich enzyme - linked immunosorbent assay (ELISA) - 8 (IL - 8) levels. Results: The levels of serum ICAM - 1, TNF - α and IL - 8 in patients with chronic hepatitis B were significantly higher than those in controls (P <0.01). Conclusion: The levels of serum ICAM - 1, TNF - α and IL - 8 in patients with chronic hepatitis B can reflect the degree of liver damage. Detection of serum levels of ICAM - 1, TNF - α and IL - 8 in patients with chronic hepatitis B has certain clinical value in judging the condition and prognosis of patients