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目的探讨白血病患者的p53基因缺失情况及其临床意义。方法使用I-FISH回顾性分析37例复杂核型异常及25例非复杂核型异常的白血病患者的p53基因异常的情况。结果 37例复杂核型异常的白血病患者p53基因的缺失频率为46.01%(17/37),25例非复杂核型异常的缺失频率为4.00%(1/25),两者之间差异有统计学意义(P<0.01)。其中13例伴复杂核型的急性白血病患者完全缓解率(CR)15.40%,中位生存时间(MST)105d。结论 I-FISH可以快速、准确、灵敏的检测出p53基因的缺失,伴复杂核型的白血病患者p53基因缺失频率较高,CR率低,MST较短。
Objective To investigate the p53 gene deletion in patients with leukemia and its clinical significance. Methods I-FISH was used to retrospectively analyze the p53 gene abnormalities in 37 patients with complex karyotypes and 25 non-complex karyotypic abnormalities. Results The frequency of p53 gene deletion in 37 patients with abnormal karyotype was 46.01% (17/37), and the frequency of deletion of 25 cases of non-complex karyotype was 4.00% (1/25). The difference was statistically significant Significance (P <0.01). Thirteen patients with complicated karyotype acute leukemia had a complete response rate (CR) of 15.40% and a median survival time (MST) of 105 days. Conclusions I-FISH can detect the loss of p53 gene rapidly, accurately and sensitively. The frequency of p53 gene deletion, high CR rate and short MST in patients with complicated karyotype leukemia were higher.