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在头颈部恶性肿瘤的综合治疗中,化疗仍是重要手段之一,化疗失败的原因主要归于肿瘤细胞的多药耐药性。虽然对恶性肿瘤多药耐药性的研究已有十余年的历史,在肿瘤耐药性的机制、逆转及应用耐药基因治疗等方面已取得了一定的进展,但在临床应用尤其是头颈部恶性肿瘤的治疗中仍甚少,由于其前景可观,对临床指导化疗的意义深远,因此巳引起不少学者的重视和研究。现就该方面的研
In the comprehensive treatment of head and neck malignancy, chemotherapy is still one of the important means. The reason of chemotherapy failure is mainly attributed to the multidrug resistance of tumor cells. Although the study of multidrug resistance of malignant tumors has a history of more than ten years, certain progresses have been made in the mechanism of tumor resistance, reversal, and application of drug resistance gene therapy, but in clinical applications, especially the head In the treatment of cervical malignant tumors, there are still very few. Because of its promising prospects, it is of far-reaching significance for clinical guidance of chemotherapy. Therefore, many scholars have paid attention and research. Now on the research