The deep drawing of titanium thin-walled surface part was simulated based on a self-developed three-dimensional finite element model. After an investigation on forming rules, a virtual orthogonal experimental design was adopted to determine the significance of processing parameters, such as die radius, blank holder force, and friction coefficient, on the forming process. The distributions of thickness and equivalent plastic strain of the drawn part were evaluated. The results show that die radius has a relative major influence on the deep drawing process, followed by friction coefficient and blank holder force.