目的设计合成3β,12β,20,25-四羟基-达玛烷(25-OH-PPD)的衍生物,并确定其结构。方法以25-OH-PPD为原料,以DCC、DMAP为催化剂,在室温下与饱和脂肪酸进行酯化反应得到一系列不同位置取代的25-OH-PPD酯类衍生物,经IR、13C-NMR、HR-MS确证其结构。结果与结论设计并合成了8个未见文献报道的人参皂苷元25-OH-PPD衍生物。该工艺条件温和,易于操作,为原人参二醇型衍生物的构效关系研究奠定基础。 OBJECTIVE To design and synthesize the derivatives of 3β, 12β, 20,25-tetrahydroxy-dammarane (25-OH-PPD) and to determine its structure. Methods A series of 25-OH-PPD ester derivatives substituted with different positions were prepared by esterification of 25-OH-PPD with DCC and DMAP at room temperature with saturated fatty acids. The compounds were characterized by IR, 13C-NMR , HR-MS confirmed its structure. RESULTS AND CONCLUSIONS Eight novel 25-OH-PPD derivatives of ginsenoside were designed and synthesized. The process conditions are mild and easy to operate, laying a foundation for the study of the structure-activity relationship of the original derivatives of the ginseng diol.