论文部分内容阅读
目的 针对恶性肿瘤具有转移至远离原发灶其它器官的生物特性。方法 将自体肿瘤或自体肿瘤培养细胞制成疫苗,分别进行动物试验。结果 肿瘤疫苗能抑制实体瘤生成并能阻止肿瘤转移,且能抵抗一次尾静脉注入2×10~5个癌细胞,即使注入的癌细胞增多肺内转移率也较对照组明显降低(P<0.01)。结论 肿瘤疫苗可以激发杀伤肿瘤细胞的特异性免疫应答,提高IL—2及TNF活性,而巨噬细胞也有介导肿瘤溶解,减少和消灭实验动物体内肿瘤的转移作用。
Aims To treat malignant tumors with biological characteristics that shift away from other organs in the primary tumor. Methods The autologous tumor or autologous tumor cell culture was made into vaccines, respectively, for animal experiments. Results The tumor vaccine could inhibit the growth of solid tumors and prevent tumor metastasis, and it was able to resist the injection of 2 × 10 ~ 5 cancer cells into the tail vein. Even if the injected cancer cells increased the lung metastasis rate was significantly lower than that of the control group (P <0.01 ). Conclusion The tumor vaccine can stimulate the specific immune response to kill tumor cells and increase the activity of IL-2 and TNF. However, macrophages also mediate tumor lysis and reduce and eliminate the tumor metastasis in experimental animals.