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目的:探讨陈氏滋阴降火法治疗女童中枢性性早熟的临床疗效。方法:对31例患儿应用陈氏滋阴降火法治疗,基础方以知柏地黄丸随症加减,6月为1疗程,每月观察患儿症状体征、血浆雌二醇(E2)、血清促黄体生成素(LH)、血清促卵泡刺激素(FSH)、妇科超声改善情况。结果:治疗1月后,E2水平下降(P<0.05),但对LH、FSH无明显影响(P>0.05);治疗6月后,E2与治疗前无明显差异(P<0.05),LH、FSH则均较治疗前升高(P<0.05)。治疗1月后,卵巢容积较前明显减少(P<0.05),但对子宫容积无明显改善(P>0.05);治疗6月后,卵巢容积、子宫容积均较治疗前无明显改善(P>0.05)。治疗1月疗效较佳,总有效率为90.32%;治疗6月后,总效率降至80.65%。显效病例的发病年龄、就诊年龄、首诊骨龄都比其他疗效等级的患儿小。结论:滋阴降火法治疗女童中枢性性早熟早期疗效肯定,早期治疗疗效更佳。
Objective: To investigate the curative effect of Chen’s nourishing yin and lowering fire on the central precocious puberty in girls. Methods: 31 cases of children with Chen Ziyin down fire treatment, the basis of Zhibai Dihuang Wan with the disease plus or minus, June for a course of treatment, monthly observation of children with signs and symptoms, plasma estradiol (E2) , Serum luteinizing hormone (LH), serum follicle stimulating hormone (FSH), gynecological ultrasound to improve the situation. Results: After 1 month of treatment, E2 level decreased (P <0.05), but had no significant effect on LH and FSH (P> 0.05). After 6 months of treatment, there was no significant difference between E2 and before treatment (P <0.05) FSH were higher than before treatment (P <0.05). After 1 month of treatment, the volume of the ovary decreased significantly (P <0.05), but the volume of the uterus was not significantly improved (P> 0.05). After 6 months of treatment, the ovarian volume and the uterine volume were not significantly improved (P> 0.05). Treatment of January efficacy is better, the total effective rate was 90.32%; after 6 months of treatment, the total efficiency dropped to 80.65%. Significant cases of the age of onset, the age of treatment, the first diagnosis of bone age than other therapeutic effect of small children. Conclusion: Ziyinjiangdu treatment of central precocious puberty in girls early effect is sure, early treatment is better.